A one month feeding experiment was carried out to investigate the influence of replacing chemically treated Terminalia catappa fruit waste (TCFW) for maize on performance, blood constituents and some biochemical determinants in pullet chicks. 144-day old (Silver brown high line) breed of chicks were randomly distributed to six dietary treatments. The diets were formulated to be iso-nitrogenous and iso-caloric and made of a corn-soy reference diet and five diets with or without TCFW. TCFW was pre-treated with the chemical detoxifier, povidone and supplemented with or without the enzyme, nutrase xyla. The experiment was designed as a 3 x 2 factorial with three levels of TCFW replacing 0, 50 100% maize and the enzyme supplemented at 0 and 100%. There were statistically significant differences in feed consumption and efficiency of feed utilization (p < 0.05). However, there was no significant difference in weight gain (p > 0.05). High mortality was recorded on diets containing high levels of TCFW. There were significant differences in blood corpuscles (WBC, Hg) as well as in packed cell volume (PCV) (p < 0.05). Significant differences were also recorded on the blood corpuscle differential count (p < 0.05). Dietary TCFW influenced enzyme activities namely the transaminase and alkaline phosphatase (p < 0.05). Significant difference was observed on the concentration of the biochemical metabolites, urate and ammonia (p < 0.05). In most of the parameters studied, values decreased with the increasing level of TCFW in diets. It was inferred that povidone treated TCFW could be incorporated at 50% in diets for poultry when treated with povidone.